2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000



Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A. 2009;106(51):21783-21788. doi:10.1073/pnas.0912274106

Nguyen DN, Chen SCY, Lu J, et al. Drug delivery-mediated control of RNA immunostimulation. Mol Ther. 2009;17(9):1555-1562. doi:10.1038/mt.2009.147

Chervin AS, Stone JD, Holler PD, et al. The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol. 2009;183(2):1166-1178. doi:10.4049/jimmunol.0900054

Lu JJ, Langer R, Chen J. A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery. Mol Pharm. 2009;6(3):763-771. doi:10.1021/mp900023v

Leptihn S, Har JY, Chen J, Ho B, Wohland T, Ding JL. Single molecule resolution of the antimicrobial action of quantum dot-labeled sushi peptide on live bacteria. BMC Biol. 2009;7:22. doi:10.1186/1741-7007-7-22

Talay O, Shen CH, Chen L, Chen J. B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proc Natl Acad Sci U S A. 2009;106(8):2741-2746. doi:10.1073/pnas.0813367106

Hu Y, Atukorale PU, Lu JJ, et al. Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles. Biomacromolecules. 2009;10(4):756-765. doi:10.1021/bm801199z

Mahajan VS, Drake A, Chen J. Virus-specific host miRNAs: antiviral defenses or promoters of persistent infection? Trends Immunol. 2009;30(1):1-7. doi:10.1016/

Guttormsen HK, Stuart L, Shi L, et al. Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination. Clin Immunol. 2009;130(3):264-271. doi:10.1016/j.clim.2008.09.012

Back to top.



Cheung AF, Dupage MJP, Dong HK, Chen J, Jacks T. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res. 2008;68(22):9459-9468. doi:10.1158/0008-5472.CAN-08-2634

Bai A, Higham E, Eisen HN, Wittrup KD, Chen J. Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice. PNAS. 2008;105(35):13003-13008. doi:10.1073/pnas.0805599105

Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J. Interleukin-7 receptor signaling network: an integrated systems perspective. Cell Mol Immunol. 2008;5(2):79-89. doi:10.1038/cmi.2008.10

Leng Q, Nie Y, Zou Y, Chen J. Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development. BMC Immunol. 2008;9:51. doi:10.1186/1471-2172-9-51

Kocher O, Yesilaltay A, Shen CH, et al. Influence of PDZK1 on lipoprotein metabolism and atherosclerosis. Biochim Biophys Acta. 2008;1782(5):310-316. doi:10.1016/j.bbadis.2008.02.004

Haldar J, Chen J, Tumpey TM, Gubareva LV, Klibanov AM. Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses. Biotechnol Lett. 2008;30(3):475-479. doi:10.1007/s10529-007-9565-5

Shen CH, Ge Q, Talay O, Eisen HN, García-Sastre A, Chen J. Loss of IL-7R and IL-15R expression is associated with disappearance of memory T cells in respiratory tract following influenza infection. J Immunol. 2008;180(1):171-178. doi:10.4049/jimmunol.180.1.171

Back to top.



Fischer MB, Rüger B, Vaculik C, et al. The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM. Eur J Immunol. 2007;37(10):2825-2833. doi:10.1002/eji.200636996

Thomas M, Lu JJ, Chen J, Klibanov AM. Non-viral siRNA delivery to the lung. Adv Drug Deliv Rev. 2007;59(2-3):124-133. doi:10.1016/j.addr.2007.03.003

Thomas M, Lu JJ, Zhang C, Chen J, Klibanov AM. Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharm Res. 2007;24(8):1564-1571. doi:10.1007/s11095-007-9279-3

Bai A, Hu H, Yeung M, Chen J. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. Journal of immunology (Baltimore, Md : 1950). 2007;178(12). doi:10.4049/jimmunol.178.12.7632

Leng Q, Ge Q, Nguyen T, Eisen HN, Chen J. Stage-dependent reactivity of thymocytes to self-peptide–MHC complexes. PNAS. 2007;104(12):5038-5043. doi:10.1073/pnas.0700674104

Back to top.



Haldar J, An D, Cienfuegos LÁ de, Chen J, Klibanov AM. Polymeric coatings that inactivate both influenza virus and pathogenic bacteria. PNAS. 2006;103(47):17667-17671. doi:10.1073/pnas.0608803103

Ge Q, Pastey M, Kobasa D, et al. Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers. Antimicrob Agents Chemother. 2006;50(11):3724-3733. doi:10.1128/AAC.00644-06

Jones B, Chen J. Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J. 2006;25(11):2443-2452. doi:10.1038/sj.emboj.7601148

Haines BB, Ryu CJ, Chen J. Recombination activating genes (RAG) in lymphoma development. Cell Cycle. 2006;5(9):913-916. doi:10.4161/cc.5.9.2732

Oestreich KJ, Cobb RM, Pierce S, Chen J, Ferrier P, Oltz EM. Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex. Immunity. 2006;24(4):381-391. doi:10.1016/j.immuni.2006.02.009

Haines BB, Ryu CJ, Chang S, et al. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell. 2006;9(2):109-120. doi:10.1016/j.ccr.2006.01.004

Ge Q, Holler PD, Mahajan VS, Nuygen T, Eisen HN, Chen J. Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc Natl Acad Sci U S A. 2006;103(6):1822-1827. doi:10.1073/pnas.0510561103

Bao M, Zhang Y, Wan M, et al. Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide. Clin Immunol. 2006;118(2-3):180-187. doi:10.1016/j.clim.2005.09.014

Back to top.



Thomas M, Ge Q, Lu JJ, Klibanov AM, Chen J. Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection. Expert Opin Biol Ther. 2005;5(4):495-505. doi:10.1517/14712598.5.4.495

Thomas M, Lu JJ, Ge Q, Zhang C, Chen J, Klibanov AM. Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. PNAS. 2005;102(16):5679-5684. doi:10.1073/pnas.0502067102

Mahajan VS, Leskov IB, Chen JZ. Homeostasis of T cell diversity. Cell Mol Immunol. 2005;2(1):1-10.

Thomas M, Ge Q, Lu JJ, Chen J, Klibanov A. Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo. Pharm Res. 2005;22(3):373-380. doi:10.1007/s11095-004-1874-y

Back to top.



Ge Q, Eisen HN, Chen J. Use of siRNAs to prevent and treat influenza virus infection. Virus Res. 2004;102(1):37-42. doi:10.1016/j.virusres.2004.01.013

Little SR, Lynn DM, Ge Q, et al. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004;101(26):9534-9539. doi:10.1073/pnas.0403549101

Ge Q, Filip L, Bai A, Nguyen T, Eisen HN, Chen J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A. 2004;101(23):8676-8681. doi:10.1073/pnas.0402486101

Ryu CJ, Haines BB, Lee HR, et al. The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion. Mol Cell Biol. 2004;24(16):7015-7023. doi:10.1128/MCB.24.16.7015-7023.2004

Kojima H, Jones BT, Chen J, Cascalho M, Sitkovsky MV. Hypoxia-Inducible Factor 1α-Deficient Chimeric Mice as a Model to Study Abnormal B Lymphocyte Development and Autoimmunity. In: Methods in Enzymology. Vol 381. Oxygen Sensing. Academic Press; 2004:218-229. doi:10.1016/S0076-6879(04)81016-4

Rudolph MG, Shen LQ, Lamontagne SA, et al. A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. J Immunol. 2004;172(5):2994-3002. doi:10.4049/jimmunol.172.5.2994

Wang C, Ge Q, Ting D, et al. Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nature Mater. 2004;3(3):190-196. doi:10.1038/nmat1075

Wang VEH, Tantin D, Chen J, Sharp PA. B cell development and immunoglobulin transcription in Oct-1-deficient mice. PNAS. 2004;101(7):2005-2010. doi:10.1073/pnas.0307304101

Ge Q, Bai A, Jones B, Eisen HN, Chen J. Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8+ T cells expressing the same or different T cell receptors. Proc Natl Acad Sci U S A. 2004;101(9):3041-3046. doi:10.1073/pnas.0307339101

Wang VEH, Schmidt T, Chen J, Sharp PA, Tantin D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol. 2004;24(3):1022-1032. doi:10.1128/MCB.24.3.1022-1032.2004

Back to top.



Ryu CJ, Haines BB, Draganov DD, et al. The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination. PNAS. 2003;100(23):13465-13470. doi:10.1073/pnas.2235807100

Rider TH, Petrovick MS, Nargi FE, et al. A B cell-based sensor for rapid identification of pathogens. Science. 2003;301(5630):213-215. doi:10.1126/science.1084920

Ge Q, Bai A, Shen CH, Eisen HN, Chen J. CD4+ T-cell responses to self-peptide--MHC. Trends Immunol. 2003;24(4):186-189. doi:10.1016/s1471-4906(03)00060-7

Chen J, Eisen HN, Kranz DM. A model T-cell receptor system for studying memory T-cell development. Microbes Infect. 2003;5(3):233-240. doi:10.1016/s1286-4579(03)00016-9

Ge Q, McManus MT, Nguyen T, et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A. 2003;100(5):2718-2723. doi:10.1073/pnas.0437841100

Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003;170(7):3819-3827. doi:10.4049/jimmunol.170.7.3819

Back to top.



Langford TD, Housley MP, Boes M, et al. Central importance of immunoglobulin A in host defense against Giardia spp. Infect Immun. 2002;70(1):11-18. doi:10.1128/IAI.70.1.11-18.2002

Ge Q, Stone JD, Thompson MT, et al. Soluble peptide–MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. PNAS. 2002;99(21):13729-13734. doi:10.1073/pnas.212515299

Boes M, Cerny J, Massol R, et al. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 2002;418(6901):983-988. doi:10.1038/nature01004

McManus MT, Haines BB, Dillon CP, et al. Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol. 2002;169(10):5754-5760. doi:10.4049/jimmunol.169.10.5754

Chen J, Ge Q, Cho B, Eise HN. T cell proliferation, differentiation, and restoration in lymphopenic individuals: for contributed volumes. Adv Exp Med Biol. 2002;512:135-139. doi:10.1007/978-1-4615-0757-4_18

McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. RNA. 2002;8(6):842-850. doi:10.1017/s1355838202024032

Ge Q, Palliser D, Eisen HN, Chen J. Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. Proc Natl Acad Sci U S A. 2002;99(5):2983-2988. doi:10.1073/pnas.052714199

Ge Q, Hu H, Eisen HN, Chen J. Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments. PNAS. 2002;99(5):2989-2994. doi:10.1073/pnas.052714099

Ge Q, Hu H, Eisen HN, Chen J. Naïve to memory T-cell differentiation during homeostasis-driven proliferation. Microbes and Infection. 2002;4(5):555-558. doi:10.1016/S1286-4579(02)01572-1

Sugawa S, Palliser D, Eisen HN, Chen J. How do cultured CD8(+) murine T cell clones survive repeated ligation of the TCR? Int Immunol. 2002;14(1):23-30. doi:10.1093/intimm/14.1.23

Back to top.



Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J. Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells. J Exp Med. 2001;194(10):1449-1459.

Whitehurst CE, Hu H, Ryu CJ, Rajendran P, Schmidt T, Chen J. Normal TCRbeta transcription and recombination in the absence of the Jbeta2-Cbeta2 intronic cis element. Mol Immunol. 2001;38(1):55-63. doi:10.1016/s0161-5890(01)00031-1

Ge Q, Rao VP, Cho BK, Eisen HN, Chen J. Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors. PNAS. 2001;98(4):1728-1733. doi:10.1073/pnas.98.4.1728

Qu CK, Nguyen S, Chen J, Feng GS. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood. 2001;97(4):911-914. doi:10.1182/blood.V97.4.911

Cho BK, Lian KC, Lee P, et al. Differences in antigen recognition and cytolytic activity of CD8+ and CD8− T cells that express the same antigen-specific receptor. PNAS. 2001;98(4):1723-1727. doi:10.1073/pnas.98.4.1723

Sieh P, Chen J. Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus. J Immunol. 2001;167(4):2121-2129. doi:10.4049/jimmunol.167.4.2121

Back to top.



Whitehurst CE, Schlissel MS, Chen J. Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms. Immunity. 2000;13(5):703-714. doi:10.1016/s1074-7613(00)00069-8

Baumgarth N, Chen J, Herman OC, Jager GC, Herzenberg LA. The role of B-1 and B-2 cells in immune protection from influenza virus infection. Curr Top Microbiol Immunol. 2000;252:163-169. doi:10.1007/978-3-642-57284-5_17

Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J. SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. Genomics. 2000;68(1):93-96. doi:10.1006/geno.2000.6279

Sleckman BP, Bassing CH, Hughes MM, et al. Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments. PNAS. 2000;97(14):7975-7980. doi:10.1073/pnas.130190597

Cho BK, Rao VP, Ge Q, Eisen HN, Chen J. Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells. J Exp Med. 2000;192(4):549-556.

Baumgarth N, Herman OC, Jager GC, Brown LE, Herzenberg LA, Chen J. B-1 and B-2 Cell–Derived Immunoglobulin M Antibodies Are Nonredundant Components of the Protective Response to Influenza Virus Infection. J Exp Med. 2000;192(2):271-280.

Cho BK, Palliser D, Guillen E, et al. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity. 2000;12(3):263-272. doi:10.1016/s1074-7613(00)80179-x

Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci U S A. 2000;97(3):1184-1189. doi:10.1073/pnas.97.3.1184

Kuzin II, Ugine GD, Wu D, Young F, Chen J, Bottaro A. Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts. J Immunol. 2000;164(3):1451-1457. doi:10.4049/jimmunol.164.3.1451

Kim M, Qiu P, Abuodeh R, Chen J, Yuan D. Differential regulation of transcription termination occurring at two different sites on the micro-delta gene complex. Int Immunol. 1999;11(5):813-824. doi:10.1093/intimm/11.5.813

Back to top.

Search PubMed for Chen Lab Publications.