2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010
2019
Liu X, Li F, Niu H, et al. IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation. Frontiers in Immunology. 2019;10:2350. doi:10.3389/fimmu.2019.02350
Hu G, Dong T, Wang S, Jing H, Chen J. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. EBioMedicine. 2019;45:563-577. doi:10.1016/j.ebiom.2019.06.039
Uppu DSSM, Turvey ME, Sharif ARM, et al. Temporal release of a three-component protein subunit vaccine from polymer multilayers. J Control Release. 2020;317:130-141. doi:10.1016/j.jconrel.2019.11.022
Hou J, Shrivastava S, Fraser CC, et al. Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice. Frontiers in Immunology. 2019;10:1429. doi:10.3389/fimmu.2019.01429
Roghanian A, Hu G, Fraser C, et al. Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression. Cancer Immunol Res. 2019;7(11):1876-1890. doi:10.1158/2326-6066.CIR-18-0835
Bidet K, Ho V, Chu CW, et al. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. npj Vaccines. 2019;4(1):1-13. doi:10.1038/s41541-019-0119-3
Kaur M, Drake AC, Hu G, et al. Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice. J Immunol. 2019;202(6):1885-1894. doi:10.4049/jimmunol.1800366
2018
Zheng D, Chen J. Culture and Differentiation of Lung Bronchiolar Epithelial Cells In Vitro. Methods Mol Biol. 2018;1817:33-40. doi:10.1007/978-1-4939-8600-2_4
Ye W, Chew M, Hou J, et al. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PLoS Pathog. 2018;14(10):e1007298. doi:10.1371/journal.ppat.1007298
Chen H, Cho KS, Vu THK, et al. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun. 2018;9(1):3209. doi:10.1038/s41467-018-05681-9
2017
Wang S, Zhang J, Sui L, et al. Antibiotics induce polarization of pleural macrophages to M2-like phenotype in patients with tuberculous pleuritis. Sci Rep. 2017;7(1):14982. doi:10.1038/s41598-017-14808-9
Ivica NA, Kaur M, Hu G, Chen J. Information-dense analysis for information-dense understanding. Transl Cancer Res. 2016;5(Suppl 6):S1078-S1081. doi:10.21037/tcr.2016.11.21
Jiang W, von Roemeling CA, Chen Y, et al. Designing nanomedicine for immuno-oncology. Nat Biomed Eng. 2017;1(2):1-11. doi:10.1038/s41551-017-0029
Costa VV, Ye W, Chen Q, et al. Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. mBio. 2017;8(4):e00741-17. doi:10.1128/mBio.00741-17
Roper J, Tammela T, Cetinbas NM, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol. 2017;35(6):569-576. doi:10.1038/nbt.3836
Cui L, Hou J, Fang J, et al. Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection. J Virol. 2017;91(14):e00386-17. doi:10.1128/JVI.00386-17
Zheng D, Soh BS, Yin L, et al. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro. Sci Rep. 2017;7(1):41661. doi:10.1038/srep41661
2016
Drake A, Kaur M, Iliopoulou BP, Phennicie R, Hanson A, Chen J. Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling. PLoS One. 2016;11(11):e0166280. doi:10.1371/journal.pone.0166280
Roghanian A, Fraser C, Kleyman M, Chen J. B Cells Promote Pancreatic Tumorigenesis. Cancer Discov. 2016;6(3):230-232. doi:10.1158/2159-8290.CD-16-0100
Cui L, Zheng D, Lee YH, et al. Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia. Sci Rep. 2016;6(1):26076. doi:10.1038/srep26076
Lai J, Tan WJ, Too CT, et al. Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities. Blood. 2016;128(10):1396-1407. doi:10.1182/blood-2016-03-707836
Keng CT, Sze CW, Zheng D, et al. Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection. Gut. 2016;65(10):1744-1753. doi:10.1136/gutjnl-2014-307856
2015
Chen Q, Ye W, Jian Tan W, et al. Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human. Sci Rep. 2015;5(1):15118. doi:10.1038/srep15118
Niu H, Peng J, Bai C, et al. Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice. PLoS One. 2015;10(6):e0130641. doi:10.1371/journal.pone.0130641
Robinson LN, Tharakaraman K, Rowley KJ, et al. Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Cell. 2015;162(3):493-504. doi:10.1016/j.cell.2015.06.057
Amaladoss A, Chen Q, Liu M, et al. De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection. PLoS One. 2015;10(6):e0129825. doi:10.1371/journal.pone.0129825
Guo H, Zhang J, Zhang X, et al. SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7. J Immunol. 2015;194(10):4737-4749. doi:10.4049/jimmunol.1402312
Zenonos ZA, Dummler SK, Müller-Sienerth N, et al. Basigin is a druggable target for host-oriented antimalarial interventions. J Exp Med. 2015;212(8):1145-1151. doi:10.1084/jem.20150032
Li Y, Shen C, Zhu B, Shi F, Eisen HN, Chen J. Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells. J Immunol. 2015;195(4):1591-1598. doi:10.4049/jimmunol.1500451
Liu H, Elkin I, Chen J, Klibanov AM. Why do some immobilized N-alkylated polyethylenimines far surpass others in inactivating influenza viruses? Biomacromolecules. 2015;16(1):351-356. doi:10.1021/bm5015427
2014
Dighe N, Khoury M, Mattar C, et al. Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector. PLoS One. 2014;9(8):e104805. doi:10.1371/journal.pone.0104805
Chen Q, Amaladoss A, Ye W, et al. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A. 2014;111(4):1479-1484. doi:10.1073/pnas.1323318111
Kumar Y, Liang C, Limmon GV, et al. Molecular analysis of serum and bronchoalveolar lavage in a mouse model of influenza reveals markers of disease severity that can be clinically useful in humans. PLoS One. 2014;9(2):e86912. doi:10.1371/journal.pone.0086912
Yin L, Zheng D, Limmon GV, et al. Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respir Res. 2014;15(1):116. doi:10.1186/s12931-014-0116-z
Pallasch CP, Leskov I, Braun CJ, et al. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell. 2014;156(3):590-602. doi:10.1016/j.cell.2013.12.041
Weight AK, Belser JA, Tumpey TM, Chen J, Klibanov AM. Zanamivir conjugated to poly-L-glutamine is much more active against influenza viruses in mice and ferrets than the drug itself. Pharm Res. 2014;31(2):466-474. doi:10.1007/s11095-013-1175-4
Zheng D, Yin L, Chen J. Evidence for Scgb1a1(+) cells in the generation of p63(+) cells in the damaged lung parenchyma. Am J Respir Cell Mol Biol. 2014;50(3):595-604. doi:10.1165/rcmb.2013-0327OC
2013
Sim ACN, Too CT, Oo MZ, et al. Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies. Sci Rep. 2013;3(1):3232. doi:10.1038/srep03232
Wu A, Su C, Wang D, et al. Sequential reassortments underlie diverse influenza H7N9 genotypes in China. Cell Host Microbe. 2013;14(4):446-452. doi:10.1016/j.chom.2013.09.001
Bak SP, Barnkob MS, Wittrup KD, Chen J. CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate. Cancer Immunol Res. 2013;1(6):393-401. doi:10.1158/2326-6066.CIR-13-0109
Hu G, Chen J. A Genome-wide Regulatory Network Identifies Key Transcription Factors for Memory CD8+ T Cell Development. Nat Commun. 2013;4:2830. doi:10.1038/ncomms3830
Zhu Y, Yao S, Iliopoulou BP, et al. B7-H5 costimulates human T cells via CD28H. Nat Commun. 2013;4(1):2043. doi:10.1038/ncomms3043
Larson AM, Chen J, Klibanov AM. Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. J Pharm Sci. 2013;102(8):2450-2459. doi:10.1002/jps.23644
Sridharan A, Chen Q, Tang KF, Ooi EE, Hibberd ML, Chen J. Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. J Virol. 2013;87(21):11648-11658. doi:10.1128/JVI.01156-13
Li Y, Chen Q, Zheng D, et al. Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice. J Immunol. 2013;191(6):3192-3199. doi:10.4049/jimmunol.1300742
Feijó Delgado F, Cermak N, Hecht VC, et al. Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells. PLoS One. 2013;8(7):e67590. doi:10.1371/journal.pone.0067590
Zheng D, Limmon GV, Yin L, et al. A cellular pathway involved in Clara cell to alveolar type II cell differentiation after severe lung injury. PLoS One. 2013;8(8):e71028. doi:10.1371/journal.pone.0071028
Yin L, Xu S, Cheng J, et al. Spatiotemporal quantification of cell dynamics in the lung following influenza virus infection. J Biomed Opt. 2013;18(4):046001. doi:10.1117/1.JBO.18.4.046001
Chen Q, Khoury M, Limmon G, Choolani M, Chan JKY, Chen J. Human fetal hepatic progenitor cells are distinct from, but closely related to, hematopoietic stem/progenitor cells. Stem Cells. 2013;31(6):1160-1169. doi:10.1002/stem.1359
Li N, Yin L, Thévenin D, et al. Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol. 2013;8(2):257-269. doi:10.2217/fmb.12.134
2012
Zheng D, Limmon GV, Yin L, et al. Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza. PLoS One. 2012;7(10):e48451. doi:10.1371/journal.pone.0048451
Chen Q, He F, Kwang J, Chan JKY, Chen J. GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation. J Immunol. 2012;189(11):5223-5229. doi:10.4049/jimmunol.1201789
Lee CM, Weight AK, Haldar J, Wang L, Klibanov AM, Chen J. Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection. Proc Natl Acad Sci U S A. 2012;109(50):20385-20390. doi:10.1073/pnas.1219155109
Soh BS, Zheng D, Li Yeo JS, et al. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol Ther. 2012;20(12):2335-2346. doi:10.1038/mt.2012.182
Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ. Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Biomaterials. 2012;33(23):5776-5787. doi:10.1016/j.biomaterials.2012.04.029
Larson AM, Wang H, Cao Y, Jiang T, Chen J, Klibanov AM. Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity. J Pharm Sci. 2012;101(10):3896-3905. doi:10.1002/jps.23253
Bak SP, Barnkob MS, Bai A, Higham EM, Wittrup KD, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189(4):1708-1716. doi:10.4049/jimmunol.1201271
Nguyen DN, Mahon KP, Chikh G, et al. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. PNAS. 2012;109(14):E797-E803. doi:10.1073/pnas.1121423109
Drake AC, Chen Q, Chen J. Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol. 2012;9(3):215-224. doi:10.1038/cmi.2012.6
Eisen HN, Hou XH, Shen C, et al. Promiscuous binding of extracellular peptides to cell surface class I MHC protein. PNAS. 2012;109(12):4580-4585. doi:10.1073/pnas.1201586109
Yamada Y, Limmon GV, Zheng D, et al. Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. PLoS One. 2012;7(2):e31494. doi:10.1371/journal.pone.0031494
Ong LM, Fan X, Chu PPY, et al. Cotransplantation of ex vivo expanded and unexpanded cord blood units in immunodeficient mice using insulin growth factor binding protein-2-augmented mesenchymal cell cocultures. Biol Blood Marrow Transplant. 2012;18(5):674-682. doi:10.1016/j.bbmt.2012.01.001
Hong J, Shah NJ, Drake AC, et al. Graphene Multilayers as Gates for Multi-Week Sequential Release of Proteins from Surfaces. ACS Nano. 2012;6(1):81-88. doi:10.1021/nn202607r
Panneerselvam P, Singh LP, Ho B, Chen J, Ding JL. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. Biochem J. 2012;442(2):263-271. doi:10.1042/BJ20111653
2011
Chen SCY, Stern P, Guo Z, Chen J. Expression of Multiple Artificial MicroRNAs from a Chicken miRNA126-Based Lentiviral Vector. PLoS One. 2011;6(7):e22437. doi:10.1371/journal.pone.0022437
Olurinde MO, Shen CH, Drake A, Bai A, Chen J. Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent. Cell Mol Immunol. 2011;8(5):415-423. doi:10.1038/cmi.2011.18
Cao Y, Koh X, Dong L, et al. Rapid Estimation of Binding Activity of Influenza Virus Hemagglutinin to Human and Avian Receptors. PLoS One. 2011;6(4):e18664. doi:10.1371/journal.pone.0018664
Drake AC, Khoury M, Leskov I, et al. Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice. PLoS One. 2011;6(4):e18382. doi:10.1371/journal.pone.0018382
Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309. doi:10.1016/j.cell.2011.01.004
Hsu BB, Wong SY, Hammond PT, Chen J, Klibanov AM. Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations. PNAS. 2011;108(1):61-66. doi:10.1073/pnas.1017012108
Yang W, Ding X, Deng J, et al. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med (Berl). 2011;89(4):399-409. doi:10.1007/s00109-010-0711-5
Larson AM, Hsu BB, Rautaray D, Haldar J, Chen J, Klibanov AM. Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions. Biotechnol Bioeng. 2011;108(3):720-723. doi:10.1002/bit.22967
Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011;89(5):581-594. doi:10.1038/icb.2011.5
Weight AK, Haldar J, Alvarez de Cienfuegos L, et al. Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus. J Pharm Sci. 2011;100(3):831-835. doi:10.1002/jps.22338
Khoury M, Drake A, Chen Q, et al. Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev. 2011;20(8):1371-1381. doi:10.1089/scd.2010.0456
DuPage M, Cheung AF, Mazumdar C, et al. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell. 2011;19(1):72-85. doi:10.1016/j.ccr.2010.11.011
Ding X, Yang W, Shi X, et al. TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms. J Immunol. 2011;187(3):1184-1191. doi:10.4049/jimmunol.1002902
2010
Zhang L, Meissner E, Chen J, Su L. Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci. 2010;53(2):195-203. doi:10.1007/s11427-010-0059-7
Higham EM, Shen CH, Wittrup KD, Chen J. Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model. J Immunol. 2010;184(11):5954-5958. doi:10.4049/jimmunol.1000265
Low DHP, Frecer V, Le Saux A, et al. Molecular interfaces of the galactose-binding protein Tectonin domains in host-pathogen interaction. J Biol Chem. 2010;285(13):9898-9907. doi:10.1074/jbc.M109.059774
Shen CH, Talay O, Mahajan VS, Leskov IB, Eisen HN, Chen J. Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues. PNAS. 2010;107(52):22587-22592. doi:10.1073/pnas.1016350108
Haldar J, Alvarez de Cienfuegos L, Tumpey TM, Gubareva LV, Chen J, Klibanov AM. Bifunctional polymeric inhibitors of human influenza A viruses. Pharm Res. 2010;27(2):259-263. doi:10.1007/s11095-009-0013-1
Higham EM, Wittrup KD, Chen J. Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand. J Immunol. 2010;184(7):3394-3400. doi:10.4049/jimmunol.0903111