1999 | 1998 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990



Cho BK, Wang C, Sugawa S, Eisen HN, Chen J. Functional differences between memory and naive CD8 T cells. Proc Natl Acad Sci U S A. 1999;96(6):2976-2981.

Whitehurst CE, Chattopadhyay S, Chen J. Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter. Immunity. 1999;10(3):313-322. doi:10.1016/s1074-7613(00)80031-x

Wang B, Wang N, Whitehurst CE, She J, Chen J, Terhorst C. T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta. J Immunol. 1999;162(1):88-94.




Boes M, Prodeus AP, Schmidt T, Carroll MC, Chen J. A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection. J Exp Med. 1998;188(12):2381-2386.

Chattopadhyay S, Whitehurst CE, Chen J. A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression. J Biol Chem. 1998;273(45):29838-29846. doi:10.1074/jbc.273.45.29838

Bottaro A, Young F, Chen J, Serwe M, Sablitzky F, Alt FW. Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus. Int Immunol. 1998;10(6):799-806. doi:10.1093/intimm/10.6.799

Boes M, Esau C, Fischer MB, Schmidt T, Carroll M, Chen J. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol. 1998;160(10):4776-4787.

Chattopadhyay S, Whitehurst CE, Schwenk F, Chen J. Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation. J Immunol. 1998;160(3):1256-1267.

Chen J and Alt FW. Generation of antigen receptor diversity. In Exploring Genetic Mechanisms, ed. Berg P and Singer M.  University Science Books, Sausalito, California. P337-404.

Chen, J. and Alt, F. W., “Overview: Immunoglobulin gene rearrangement and switching,” Weir’s Handbook of Experimental Immunology, edited by Herzenberg, L. A., Weir, D. M., Herzenberg, L. A. and Blackwell, C., Blackwell Science, Inc. Cambridge, MA, 5th edition, 1996, pp15.1-15.5.

Back to top.



Chen J. Analysis of Gene Function in Lymphocytes by RAG-2-Deficient Blastocyst Complementation. In: Dixon FJ, ed. Advances in Immunology. Vol 62. Academic Press; 1996:31-59. doi:10.1016/S0065-2776(08)60427-7

Zhang BW, Zimmer G, Chen J, et al. T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996;183(2):413-420. doi:10.1084/jem.183.2.413

Lansford R, Okada A, Chen J, Oltz EM, Blackwell K, Alt FW, Rathbun G. (1996)  Mechanism and control of immunoglobulin gene rearrangement. In: Molecular Immunology, ed. Hames BD and Glover DM. IRL Press at Oxford University, P1-100.




Ma A, Datta M, Margosian E, Chen J, Horak I. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med. 1995;182(5):1567-1572. doi:10.1084/jem.182.5.1567

Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3(4):521-530. doi:10.1016/1074-7613(95)90180-9




Tsai FY, Keller G, Kuo FC, et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994;371(6494):221-226. doi:10.1038/371221a0

Chen J, Ma A, Young F, Alt FW. IL-2 receptor alpha chain expression during early B lymphocyte differentiation. Int Immunol. 1994;6(8):1265-1268. doi:10.1093/intimm/6.8.1265

Alt FW, Chen J. The Use of Targeted Mutations in ES Cells to Create Novel Immunodeficient Mouse Models. In: Eibl MM, Huber C, Peter HH, Wahn U, eds. Symposium in Immunology III. Springer; 1994:45-59. doi:10.1007/978-3-642-78438-5_6

Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW. Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity. 1994;1(1):65-72. doi:10.1016/1074-7613(94)90010-8

Chen J, Shinkai Y, Young F, Alt FW. Probing immune functions in RAG-deficient mice. Curr Opin Immunol. 1994;6(2):313-319. doi:10.1016/0952-7915(94)90107-4

Back to top.



Chen J, Young F, Bottaro A, Stewart V, Smith RK, Alt FW. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 1993;12(12):4635-4645.

Oltz EM, Alt FW, Lin WC, et al. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol. 1993;13(10):6223-6230.

Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Curr Biol. 1993;3(7):405-413. doi:10.1016/0960-9822(93)90347-q

Chen J, Trounstine M, Alt FW, et al. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol. 1993;5(6):647-656. doi:10.1093/intimm/5.6.647

Chen J, Alt FW. Gene rearrangement and B-cell development. Current Opinion in Immunology. 1993;5(2):194-200. doi:10.1016/0952-7915(93)90004-C

Chen J, Trounstine M, Kurahara C, et al. B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J. 1993;12(3):821-830.




Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J. VDJ recombination. Immunology Today. 1992;13(8):306-314. doi:10.1016/0167-5699(92)90043-7




Chen J, Herzenberg LA, Herzenberg LA. Heparin alters the expression of different forms of immunoglobulin mu heavy chains and their associated proteins by pre-B cell lines and normal Ly-1 (CD5+) B cells. Int Immunol. 1991;3(11):1117-1127. doi:10.1093/intimm/3.11.1117




Chen JZ, Herzenberg LA, Herzenberg LA. Heparin inhibits EcoRI endonuclease cleavage of DNA at certain EcoRI sites. Nucleic Acids Res. 1990;18(11):3255-3260.

Chen JZ, Stall AM, Herzenberg LA, Herzenberg LA. Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals. EMBO J. 1990;9(7):2117-2124.

Back to top.

Search PubMed for Chen Lab publications.