Research

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Our research seeks fundamental understanding of the immune system as well as its application in cancer immunotherapy and vaccine development. We study molecular and cellular mechanisms of immunological and disease processes by taking advantage of the vast array of genomic data, humanized mice and clinical samples.

Our research is carried out at the Koch Institute for Integrative Cancer Research at MIT in Cambridge, Massachusetts and at the Singapore-MIT Alliance for Research and Technology (SMART) in Singapore.

Modeling Diseases and Treatments in Humanized Mice

Modeling diseases and treatments in humanized mice

We have made significant contributions to the development of the humanized mouse technology by i) expanding HSCs in vitro for large scale construction of humanized mice, ii) expressing human cytokines in recipient mice to enhance the reconstitution and function of human immune cells, including myeloid lineage cells, and iii) generating humanized mice with human liver cells and matching human immune system. more >>

Macrophages in Immunity and Diseases

Macrophages in immunity and diseases

. We are interested in alveolar macrophages in the lung, especially their role in asthma, chronic obstructive pulmonary disease (COPD) and responses to Mycobacterium tuberculosis (TB) infection. more >>